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  7. Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/1902)

Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/1902)

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Fig. 1: Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with Nucleophosmin-Monospecific Mouse Monoclonal Antibody (NPM1/1902).

Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/1902)
Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/1902)
Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/1902)
Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/1902)

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Fig. 1: Formalin-fixed, paraffin-embedded human Basal Cell Carcinoma stained with Nucleophosmin-Monospecific Mouse Monoclonal Antibody (NPM1/1902).
Fig. 2: Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with Nucleophosmin-Monospecific Mouse Monoclonal Antibody (NPM1/1902).
Fig. 3: Western Blot Analysis of A431 cell lysate using Nucleophosmin-Monospecific Mouse Monoclonal Antibody (NPM1/1902).
Fig. 4: Analysis of Protein Array containing more than 19,000 full-length human proteins using Nucleophosmin-Monospecific Mouse Monoclonal Antibody (NPM1/1902) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

Product code: 36-2865

Clone name : NPM1/1902
Clonality : Monoclonal
Application : ELISA, WB, IHC
Reactivity : Human

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  •   20 µg

  •  100 µg

  • $199.00 

  • $459.00 

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  • Product Info
  • Antigen Details
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Amount : 100 µg
Isotype : Mouse IgG2b, kappa
Content : 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition : Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Gene : NPM1
Gene ID : 4869
Uniprot ID : P06748
Alternative Name : NO38; NPM; NPM1; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Nucleophosmin (nucleolar phosphoprotein B23 numatrin); Nucleophosmin; Nucleophosmin/nucleoplasmin family member 1; Numatrin
Immunogen Information : Recombinant human NPM1 protein fragment (aa185-287) (exact sequence is proprietary)
Recognizes a 33kDa glycoprotein, identified as Nucleophosmin (NPM). It is predominantly localized in the nucleus of cells in most tissues. NPM is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis. This phosphoprotein moves between the nucleus and the cytoplasm. It is thoµght to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. Mutations in this gene are associated with acute myeloid leukemia.The antibody may be a useful aid for classification of acute myeloid leukemia.

ELISA (Use Ab at 2-4µg/ml for coating) (Order Ab without BSA); ,Western Blot (1-2µg/ml);Immunohistochemistry (Formalin-fixed) (1-2µg/ml for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Anti-Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody(Clone: NPM1/1902)

Product code: 36-2865
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