Monoclonal Antibody to CD43 (Clone: DF-T1)
Fig.1: Cell Surface flow analysis of anti-hCD43 antibody (36-3009) in PBMC (Lymphocytes gated) using 0.5 µg/10^6 cells. Green represents isotype control (ABEOMICS); red represents anti-hCD43 antibody. Goat anti-mouse PE conjugated secondary antibody was used (ABEOMICS).
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This antibody recognizes a 95/115/135kDa (depending upon the extent of glycosylation) surface transmembrane glycoprotein, identified as CD43 (leukosialin, sialophorin, or leukocyte sialoglycoprotein). CD43 is expressed on all thymocytes and T-lymphocytes. Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome. CD43 is also found in a range of lymphoid and myeloid tumors. Expression of CD43 may be used to identify B-lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive. Since CD43 antibody stains granulocytes and their precursors, this antibody may be used as a marker for myeloid tumors. This antibody is also useful in identification and classification of T-cell malignancies.
| Purification : | Protein G Chromatography |
| Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
| Storage condition : | Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. |
Immunohistochemical analysis: 1:200-1:500, FACS analysis: 0.5-2 µg/10^6 cells, Westernblot analysis: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Nucleus, Nucleus |
| Post transnational modification: | CD43 cytoplasmic tail: Sumoylated. |
| Tissue Specificity: | Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. |
| BioGrid: | 112571. 13 interactions. |
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