Abeomics Logo
  • (0) Items
    • Items | total: $0.00 (0)
    • Your shopping cart is empty!

Abeomics Logo

Antibodies & Engineered Cell Lines™

  • Account
    • Login
    • Address Book
    • My Order
    • My Wish List
    • Open a New Ticket
  • (0) Items
    • Your shopping cart is empty!

  • About us
  • Products
      • Antibodies
        • Biosimilars
        • TLR and Innate Immunity
        • Apoptosis
        • Immunology
        • DNA methylation and Repair
        • Cell Signalling
        • Infectious Diseases
        • NF-kB Pathway
        • Cancer Marker
        • Loading Controls
        • Stem Cells
        • Development and Differentiation
        • Isotype Controls
        • Secondary Antibodies
        • Tag Antibodies
        • Miscellaneous
      • Cell Lines
        • Reporter Cell Lines
        • Stable Cell Lines
      • Ligands and Inhibitors
        • Peptide Inhibitors
        • Proteases inhibitors
        • TLR Ligands
        • Caspase Inhibitors
      • Recombinant Proteins
        • Recombinant Proteins
      • Immune-Check Point
      • Kits and Reagents
        • Other Kits
        • Luciferase reporter assay kits
        • Inhibitor Screening Kit
        • ELISA Kits
        • Molecular Biology Kits
        • Apoptosis Detection kits
        • Flowcytometry staining kits
        • Cell dissociation solutions
        • Western Blot membranes (Quick blots/ Q Blots)
      • Tissue Microarray
      • recmAb™
        • Recombinant Biosimilar Antibodies
        • Recombinant Rabbit Antibodies
        • Recombinant Mouse Antibodies
      • sdMAB ™
        • Shark sdMAB ™
        • Alpaca sdMAB ™
  • Pathways
      • All-Pathways

        View all pathways

      • interactive-pathways

        View all interactive pathways

  • Custom Service
    • Drug Discovery Screening Services
    • Stable Cell Line Development
    • Protein Production
    • Custom Antibody Development
  • Quick order
    • + Add More..

  • Support
  • Contact us
  • Distributors
  1. Catalog
  2. /
  3. Antibodies
  4. /
  5. Immunology
  6. /
  7. Monoclonal Antibody to HMGB1 (Clone: ABM2E44)

Monoclonal Antibody to HMGB1 (Clone: ABM2E44)

Share:

Fig-1: Western blot analysis of HMGB1. Anti- HMGB1 antibody (Clone: ABM2E44) was used at 2 µg/ml HepG2 lysate.

Monoclonal Antibody to HMGB1 (Clone: ABM2E44)
Monoclonal Antibody to HMGB1 (Clone: ABM2E44)

Roll over image to zoom in

   
Fig-1: Western blot analysis of HMGB1. Anti- HMGB1 antibody (Clone: ABM2E44) was used at 2 µg/ml  HepG2 lysate.
Figure 2: Intracellular staining of HeLa cells. Green represents Isotype control. Red represents Anti-HMGB1 (10-4025). 2 µg antibodies were used. Goat anti-mouse PE was used as secondary antibody.

Product code: 10-4025

Clone name : ABM2E44
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human

Shipping Info:

Order now and get it on Tuesday September 26, 2023

Same day delivery FREE on San Diego area orders placed by 1.00 PM

Local delivery areas

Same-day delivery in San Diego available for the following zip codes:

92121, 92122, 92037, 92117, 92109, 92110, 92101, 92010, 92011, 92009, 92008
Download TDS MSDS
Write a review for this product on BioCompare
Get $20 gift card from Amazon
Size
Price

Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

Add to Wish List

Bulk Order

Shipping Info:

Order now and get it on Tuesday September 26, 2023

Same day delivery FREE on San Diego area orders placed by 1.00 PM

Download TDS MSDS

  • Product Info
  • Antigen Details
  • Description
  • Application Note
  • More
  • Review   (0)
Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2b Kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : HMGB1
Gene ID : 3146
Uniprot ID : P09429
Alternative Name : HMGB1, HMG1
Immunogen Information : A partial length recombinant HMGB1 protein (amino acids 1- 200 was used as the immunogen for this antibody.

HMGB1 (High-mobility group protein B1) is a 25 kDa non-histone chromatin protein, secreted by immune cells through leaderless secretory pathway. HMGB1 supports transcription and also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. The presence of HMGB1 in the nucleus depends on posttranslational modifications. When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. HMGB1 has the ability to bend DNA in order to facilitate binding of other proteins to the DNA. HMGB1 has one important role in V(D)J recombination where act as a cofactor of the RAG complex. HMGB1 stimulates a plethora of cellular responses like inflammation, attracting inflammatory cells, recruiting stem cells and promoting their proliferation. HMGB1 is highly expressed in human kidney, tonsils, adipose tissue, adrenal cortex and amniotic fluid.

Western blot analysis: 2-4 µg/ml, Flowcytometric analysis: 2-4/10^6 Cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Nucleus, Chromosome, Cytoplasm, Secreted, Cell membrane, Endosome, Endoplasmic reticulum-Golgi intermediate compartment
Post transnational modification: In vitro cleavage by CASP1 is liberating a HMG box 1-containing peptide which may mediate immunogenic activity; the peptide antagonizes apoptosis-induced immune tolerance (PubMed:24474694). Can be proteolytically cleaved by a thrombin:thrombomodulin complex; reduces binding to heparin and proinflammatory activities (By similarity).
Tissue Specificity: Ubiquituous. Expressed in platelets (PubMed:11154118).
BioGrid: 109389. 98 interactions.
There are currently no product reviews
Write a review on this product!

Customers who purchased this product also purchased

Recombinant 2019-nCoV S Protein RBD-SD1 (C-6His)

Recombinant 2019-nCoV S Protei...

details-Recombinant 2019-nCoV S Protein RBD-SD1 (C-6His)
Anti-IL6 Antibody (siltuximab biosimilar) (CLLB8)

Anti-IL6 Antibody (siltuximab ...

details-Anti-IL6 Antibody (siltuximab biosimilar) (CLLB8)
Anti-Monkeypox B5R Antibody (Clone: ABM2F3.3E5)

Anti-Monkeypox B5R Antibody (C...

details-Anti-Monkeypox B5R Antibody (Clone: ABM2F3.3E5)
STAT6 Leeporter™ Luciferase Reporter-Ba/F3 Cell Line

STAT6 Leeporter™ Luciferase ...

details-STAT6 Leeporter™ Luciferase Reporter-Ba/F3 Cell Line
Monoclonal Antibody to Mouse CD16/32 (Clone: 2.4G2)

Monoclonal Antibody to Mouse C...

details-Monoclonal Antibody to Mouse CD16/32 (Clone: 2.4G2)
Monoclonal Antibody to CD45 / LCA (Leucocyte Marker)(Clone : SPM496)

Monoclonal Antibody to CD45 / ...

details-Monoclonal Antibody to CD45 / LCA (Leucocyte Marker)(Clone : SPM496)
Anti-Human CD194 (CCR4) (Mogamulizumab)

Anti-Human CD194 (CCR4) (Mogam...

details-Anti-Human CD194 (CCR4) (Mogamulizumab)
Anti-Cytokeratin 18 Monoclonal Antibody (Clone:DC-10)

Anti-Cytokeratin 18 Monoclonal...

details-Anti-Cytokeratin 18 Monoclonal Antibody (Clone:DC-10)

Most viewed Products

Recombinant Human Thioredoxin-Like 4A

Recombinant Human Thioredoxin-Like ...

details-Recombinant Human Thioredoxin-Like 4A
NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line

NF-kB Leeporter™ Luciferase Repor...

details-NF-kB Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)

Monoclonal Antibody to Caspase-3 (P...

details-Monoclonal Antibody to Caspase-3 (Pro and Active) (Clone: ABM1C12)
Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)

Monoclonal Antibody to Human IL-1be...

details-Monoclonal Antibody to Human IL-1beta (Clone: ABM26G5)
Polyclonal Antibody to Beta actin

Polyclonal Antibody to Beta actin

details-Polyclonal Antibody to Beta actin
Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)

Monoclonal antibody to Human PD-L1 ...

details-Monoclonal antibody to Human PD-L1 (Clone: ABM5F25)
Monoclonal Antibody to GAPDH (Clone: ABM22C5)

Monoclonal Antibody to GAPDH (Clone...

details-Monoclonal Antibody to GAPDH (Clone: ABM22C5)
Monoclonal antibody to B7-H4 (Clone: ABM53A6)

Monoclonal antibody to B7-H4 (Clone...

details-Monoclonal antibody to B7-H4 (Clone: ABM53A6)
Polyclonal Antibody to Beta Tubulin

Polyclonal Antibody to Beta Tubulin

details-Polyclonal Antibody to Beta Tubulin
Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)

Recombinant Human Indoleamine 2,3-D...

details-Recombinant Human Indoleamine 2,3-Dioxygenase/IDO/INDO (N-6His)

Related Products

Monoclonal Antibody to h/m CD11b (Clone: M1/70)

Monoclonal Antibody to h/m CD11b (Clone: M1/70)

Anti-Human CD85g FITC Mab (Clone: 17G10.2 )

Anti-Human CD85g FITC Mab (Clone: 17G10.2 )

Anti-CD79a Monoclonal Antibody (Clone:HM47)

Anti-CD79a Monoclonal Antibody (Clone:HM47)

New Products

Anti-Biotin Mab(1D4-C5)

Anti-Biotin Mab(1D4-C5)

Human APP Protein, His Tag

Human APP Protein, His Tag

Human APLP2 Protein, His Tag

Human APLP2 Protein, His Tag

close

Please Login to write a Review !!


close

Monoclonal Antibody to HMGB1 (Clone: ABM2E44)

Product code: 10-4025
*specify in mg or ml

Abeomics Logo

Antibodies & Engineered Cell Lines™

Tel : 858-263-4982

Fax : 858-247-7052

Email : support@abeomics.com

Connect with Us

  • Facebook
  • Twitter
  • Linkedin
  • YouTube

Products

  • Antibodies
  • Cell Lines
  • Ligands and Inhibitors
  • Recombinant Proteins
  • Immune-Check Point
  • Kits and Reagents
  • Tissue Microarray
  • recmAb™
  • sdMAB ™

Services

  • Drug Discovery Screening Services
  • Stable Cell Line Development
  • Protein Production
  • Custom Antibody Development

Quick order

+ Add More..

Newsletter

Posters and Flyers

© 2023 Abeomics. All rights reserved.
  • Blog
  • Sitemap
  • Terms
  • Privacy Policy
  • Legal
  • Email unsubscribe

Item added to cart successfully

No cart item available
Continue shopping View Cart