Monoclonal Antibody to IL-36R (Clone: ABM4B73)

Product code: 10-4167

Clone name : ABM4B73
Clonality : Monoclonal
Application : FACS, WB
Reactivity : Human

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Available Pack Size(s)

  •   25 µg

  •  100 µg

  • $110.00 

  • $290.00 

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Shipping Info:

Order now and get it on Thursday June 20, 2024

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Format : Purified
Amount : 100 µg
Isotype : Mouse IgG2b, kappa
Purification : Protein G Chromatography
Content : 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : IL1RL2
Gene ID : 8808
Uniprot ID : Q9HB29
Alternative Name : IL1RL2, IL1RRP2
Immunogen Information : A partial length recombinant IL-36R protein (amino acids 1-203) was used as the immunogen for this antibody.

IL-36R is a member of the IL-1 receptor family that has been associated with various inflammation-associated diseases. Ligands binding to IL-36R subsequently recruit the IL-1RAcP (IL-1 Receptor Accessory Protein) forming a heterodimeric signaling complex. The latter is also used by IL-1Alpha and IL-1 Beta. IL-36R is expressed by different immune cells, including Dendritic Cells, microglia and other myeloid cells. IL-36 stimulation of DC leads to the production of several cytokines by DC, including TNF-a, IL-1, IL-12, and IL-23. This interaction also enhances the expression of MHC class 2 and co-stimulatory molecules.

Western blot analysis: 2-4 µg/ml, Flowcytometric analysis: 0.5-1 µg/10^6 Cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Membrane
Tissue Specificity: Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
BioGrid: 114336. 11 interactions.
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