Mouse Monoclonal Antibody to Human KRT20 (Clone : 13F8)(Discontinued)
|Amount :||40 µg|
|Isotype :||Mouse IgG2b,Kappa|
|Purification :||Protein A chromatography|
|Content :||0.5 mg/ml, lyophilized with PBS, pH 7.4, containing 0.02% sodium azide.|
|Storage condition :||The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles.|
Keratin-20 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. KRT20 plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, it plays a role in the secretion of mucin in the small intestine. Diseases associated with KRT20 include Merkel cell carcinoma and ovarian Brenner tumor. Among its related pathways are cytoskeletal signaling and developmental biology.
ELISA detection: 0.01-0.1 µg/ml
Western blot: 1-2 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Post transnational modification:||Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.|
|Tissue Specificity:||Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.|
|BioGrid:||119979. 28 interactions.|