Polyclonal Antibody to Gamma-Catenin Antibody
Figure 1: Western blot analysis of extracts from HT-29, MCF-7 and C2C12 cells using g-Catenin Antibody 35-1813 .
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| Format : | Purified |
| Amount : | 100 µl |
| Isotype : | Rabbit IgG |
| Content : | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton "Characterization of the interactions of a-catenin with a-actinin and beta-catenin/plakoglobin." Nieset J.E., Redfield A.R., Jin F., et al. J. Cell Sci. 110:1013-1022(1997) "Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion." Yamamoto M., Bharti A., Li Y., Kufe D. J. Biol. Chem. 272:12492-12494(1997) "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)." Holsinger L.J., Ward K., Duffield B., Zachwieja J., Jallal B. Oncogene 21:7067-7076(2002)
Predicted MW: 83kd, Western blotting: 1:500~1:1000
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
| Subcellular location: | Cell junction, Cell junction, Cytoplasm, Membrane |
| Post transnational modification: | May be phosphorylated by FER. |
| BioGrid: | 109931. 211 interactions. |
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