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  7. Polyclonal Antibody to PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421)

Polyclonal Antibody to PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421)

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Figure 1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PAK1/PAK2/PAK3(Phospho-Thr423/Thr402/Thr421) Antibody 35-1158 (left) or the same antibody preincubated with blocking peptide(right).

Polyclonal Antibody to PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421)
Polyclonal Antibody to PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421)

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Figure 1: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PAK1/PAK2/PAK3(Phospho-Thr423/Thr402/Thr421) Antibody 35-1158 (left) or the same antibody preincubated with blocking peptide(right).
Figure 2: Immunofluorescence staining of methanol-fixed Hela cells using PAK1/PAK2/PAK3(Phospho-Thr423/Thr402/Thr421) Antibody 35-1158 .

Product code: 35-1158

Clonality : Polyclonal
Application : IHC, IF
Reactivity : Rat, Mouse, Human

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  •   50 µl

  •  100 µl

  • $349.00 

  • $412.00  $329.60 

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  • Product Info
  • Antigen Details
  • Description
  • Application Note
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Format : Purified
Amount : 100 µl
Isotype : Rabbit IgG
Content : Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : PAK1
Gene ID : 5058
Uniprot ID : Q13153
Alternative Name : p21-activated kinase 1, PAK-1, p65-PAK, Alpha-PAK
Immunogen Information : Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V) derived from Human PAK1/PAK2/PAK3.

The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695. Jung JH, et al. (2005) J Biol Chem; 280:40025-40031. Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189 Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447.

Predicted MW: 61-67 (PAK2) 68-74 (PAK1/3)kd, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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Polyclonal Antibody to PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421)

Product code: 35-1158
*specify in mg or ml

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