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    5. Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)

    Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)

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    Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)

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    Product code: 32-9385

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    •   500 µg

    •  50 µg

    • $1,535.00 

    • $464.00  $394.40 

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    Amount : 50 µg
    Content : Lyophilized from a 0.2 µm filtered solution of PBS,pH7.4.
    AA sequence : Recombinant Macaca fascicularis Cytotoxic and regulatory T-cell molecule is produced by our Mammalian expression system and the target gene encoding Ser18-Gly287 is expressed with a 6His tag at the C-terminus.
    Alternative Name : Cytotoxic and Regulatory T-Cell Molecule; Class-I MHC-Restricted T-Cell-Associated Molecule; CD355; CRTAM
    Source : Human Cells;
    Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ domain. CRTAM is expressed as a homodimer on the cell surface but does not show homotypic binding in trans. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions. IGSF4 and T cell receptor coengagement of CD8+ cells expressiong CRTAM induces increased IFNgamma or IL-22 production.
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    Recombinant Cynomolgus Cytotoxic and regulatory T-cell molecule/CRTAM(C-6His)

    Product code: 32-9385
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