Recombinant Human BTN3A1/CD277 (C-hFc)
|Amount :||50 µg|
|Content :||Lyophilized from a 0.2 um filtered solution of PBS, 5% Trehalose, 0.01%Tween 80, pH7.4|
|AA sequence :||Recombinant Human Butyrophilin Subfamily 3 Member A1 is produced by our Mammalian expression system and the target gene encoding Gln30-Gly254 is expressed with a Fc tag at the C-terminus.|
|Alternative Name :||Butyrophilin subfamily 3 member A1; CD277; BTN3A1; BTF5|
BTN3A1, also known as CD277, is a type I transmembrane glycoprotein that belongs to the Ig superfamily. BTN3A1 is expressed on various immune cells. Similar to BTN3A2 and BTN3A3, BTN3A1 is composed of an extracellular N-terminal IgV and a membrane-proximal IgC domain followed by a transmembrane domain and a cytoplasmic tail. These Ig domains are also found in B7 family co-stimulatory molecules, suggesting structural and functional similarities between the two protein families. BTN3A1 is essential for the activation of Vgamma9Vdelta2 T cells following the detection of distressed cells. The anti-tumor responses of Vgamma9Vdelta2 T cells may be enhanced with agonistic anti-BTNA3 antibodies.