Monoclonal Antibody to mouse CD180 (Clone: RP/14)(Discontinued)

Product code: 10-3502

Clone name : RP/14
Clonality : Monoclonal
Application : Functional Assay, FACS
Reactivity : Mouse

Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Write a review for this product on BioCompare
Get $20 gift card from Amazon

Shipping Info:

For estimated delivery dates, please contact us at [email protected]

Format : Purified
Amount : 500 µg
Isotype : Rat IgG2a, Kappa
Purification : Protein G Chromatography
Content : 0.5 mg, 0.2 µm filtered antibody solution in PBS containing 0.1% BSA
Storage condition : Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene : Cd180
Gene ID : 17079
Uniprot ID : Q62192
Alternative Name : CD180 antigen, Lymphocyte antigen 78, Ly-78, Radioprotective 105 kDa protein
Immunogen Information : Mouse CD180

Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105.

For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location: Cell membrane
Tissue Specificity: B-lymphocytes and spleen. Not detected in thymus, kidney, muscle, heart, brain or liver.
There are currently no product reviews

Customers who purchased this product also purchased

Most viewed Products