Monoclonal Antibody to TLR2 (Clone: ABM3A87)
|Amount :||100 µg|
|Isotype :||Mouse IgG1 Kappa|
|Purification :||Protein G Chromatography|
|Content :||25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.|
|Storage condition :||Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.|
TLR2 (Toll-Like Receptors 2) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens. TLR2 also interacts with a large number of non-TLR molecules, allowing for recognition of a great number and variety of PAMPs (pathogen-associated molecular patterns). TLR2 expression has been detected in immune cells, endothelial, and epithelial cells.
Western blot analysis: 2-4 µg/ml, FACS analysis: 0.5 µg/10^6 cells, Immunohistochemical analysis: 5 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
1. Parida R. Human MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility. Journal of Translational Autoimmunity. 2019 Apr;100002 (1). https://doi.org/10.1016/j.jtauto.2019.100002.(Immunofluorescence)
|Subcellular location:||Membrane, Cytoplasmic vesicle, Membrane raft|
|Post transnational modification:||Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.|
|Tissue Specificity:||Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.|
|BioGrid:||112952. 27 interactions.|