Angiotensin-converting enzyme 2 (ACE2) is a type I transmembrane metalloenzyme located on the outer surface of endothelial cells in the lung, arteries, heart, kidney and intestines. SARS-CoV2 uses ACE2 as the entry receptor on host cells. A better understanding of the interaction between SARS-CoV-2 and ACE2 should facilitate development of effective inhibitors of SARS-CoV-2 infection.
Angiotensin-converting enzyme 2 (ACE2) is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus, as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is the cause of COVID-19.
ACE2 Cell Lines