Biotin Conjugated, Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-229)
|Amount :||0.1 mg|
|Isotype :||Mouse IgG2a|
|Content :||Antibody suspended in phosphate buffered saline (PBS) solution containing 0.2% BSA and 15 mM sodium azide|
|Storage condition :||Store at 2-8°C. Do not freeze.|
CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Flow cytometry: Recommended dilution: 8 μg/ml; positive control: Kg1 human acute myelogenous leukemia cell line.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
|Subcellular location:||Cell membrane|
|Tissue Specificity:||Detected on umbilical veil endothelial cells (PubMed:10625079). Detected in placenta (at protein level) (PubMed:1692830). Detected on endothelial cells (PubMed:1692830).|
|BioGrid:||108337. 12 interactions.|